Midkine

• Description:

  Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK) . MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant murine Midkine is a 13.4 kDa protein containing 121 amino acid residues including five intra-molecular disulfide bonds.

• Synonyms:

  Mdk; MK; Mek

• NCBI Gene ID:

  17242

• UniProt:

  P12025

• Accession Number:

  NP_034914.1

• Accession Number mRNA:

  NM_010784.4

• Chromosomal Location:

  2 E1; 2 53.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKSK TKAKKGKGKD

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.

• Length:

  120

• Form:

  Lyophilized

• Molecular Weight:

  13.3 kDa

• Host or Source:

  E. coli