MEC (CCL28)

• Description:

  MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant murine MEC is a 12.6 kDa protein containing 111 amino acid residues.

• Synonyms:

  Ccl28; MEC; CCK1; Scya28

• NCBI Gene ID:

  56838

• UniProt:

  Q9JIL2

• Accession Number:

  NP_064675.1

• Accession Number mRNA:

  NM_020279

• Chromosomal Location:

  13; 13

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse

• Sequence:

  SEAILPMASS CCTEVSHHVS GRLLERVSSC SIQRADGDCD LAAVILHVKR RRICISPHNR TLKQWMRASE VKKNGRENVC SGKKQPSRKD RKGHTTRKHR TRGTHRHEAS R

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml.

• Length:

  111

• Form:

  Lyophilized

• Molecular Weight:

  12.6 kDa

• Host or Source:

  E. coli