MEC (CCL28)

• Description :

  MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant murine MEC is a 12.6 kDa protein containing 111 amino acid residues.

• Synonyms :

  Ccl28; MEC; CCK1; Scya28

• NCBI Gene ID :

  56838

• UniProt :

  Q9JIL2

• Accession Number :

  NP_064675.1

• Accession Number mRNA :

  NM_020279

• Chromosomal Location :

  13; 13

• Reactivity :

  Mouse

• Cross Reactivity :

  Human, Mouse

• Sequence :

  SEAILPMASS CCTEVSHHVS GRLLERVSSC SIQRADGDCD LAAVILHVKR RRICISPHNR TLKQWMRASE VKKNGRENVC SGKKQPSRKD RKGHTTRKHR TRGTHRHEAS R

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml.

• Length :

  111

• Form :

  Lyophilized

• Molecular Weight :

  12.6 kDa

• Host or Source :

  E. coli