LAG-1 (CCL4L1)

• Description:

  LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV suppressive factor. Recombinant human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.

• Synonyms:

  CCL4L1; LAG1; CCL4L; LAG-1; SCYA4L; AT744.2

• NCBI Gene ID:

  9560

• UniProt:

  P13236

• Accession Number:

  NP_001001435

• Accession Number mRNA:

  NM_001001435

• Chromosomal Location:

  100-234

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 90% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by it's ability to chemoattract CCR5 transfected cells using a concentration of 0.1-10.0 ng/ml

• Length:

  69

• Form:

  Lyophilized

• Molecular Weight:

  7.7 kDa

• Host or Source:

  E. coli