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IL-28B / IFN-lambda-3 Protein (His Tag)

CAT: 0209-M60-117-L50Size: 50 µgDry Ice: YesHazardous: No
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CAT#:0209-M60-117-L50Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, can increase the percentage of splenic CD8+ T cells in vaccinated animals and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
Synonyms
If1ia2 Protein; IFL-1 Protein; Ifnl3 Protein; IL-28B Protein; Il28 Protein; Il28b Protein; INF-alpha Protein; INF-lambda Protein
Accession Number
NP_796370.1
Reactivity
Mouse
Cross Reactivity
Mouse
Label
His-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE
Bioactivity
Measured in antiviral assay using HepG2 cells infected with vesicular stomatitisvirus (VSV) . The ED50 for this effect is 10-60ng/mL.
Length
185
Form
Lyophilized
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
21 kDa
Storage Conditions
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Host or Source
HEK 293 cells

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Alternative Products

CatalogName
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MBS2581037-01Recombinant Rat IL-28B/IFN-lambda-3 protein (His tag)
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E53A06361Recombinant Human IL-28B / IFN-lambda-3 Protein (His Tag)
IL9-H4228-50ugHuman IL-29 / IFN-lambda 1 Protein, His Tag
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591119-01IL-28B/IFN-lambda-3, Recombinant, Mouse, His-Tag discontinued
P516189IL-28B; IFN-lambda-3 Protein (N-His, Rat)
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