IL-22

CAT: 0209-M10-072-L1000Size: 1000 µgDry Ice: NoHazardous: No

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CAT#:0209-M10-072-L1000Size:1000 µg

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Description

IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 32-34 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Synonyms

IL22; IL-22; Iltif; IL-22a; ILTIFa

NCBI Gene ID

50929

UniProt

Q9JJY9

Accession Number

NP_058667.1

Accession Number mRNA

NM_016971

Chromosomal Location

10 D2; 10 67.0 cM

Reactivity

Mouse

Cross Reactivity

Mouse

Sequence

MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Assay#1: Determined by its ability to activate STAT following receptor ligand interaction. Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells) . The expected ED50 for this effect is 1.0-2.0 ng/ml.

Length

146

Form

Lyophilized

Molecular Weight

33.4 kDa

Host or Source

E. coli

UniProtKB · Q9JJY9

Interleukin-22

IL22_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: Q9JJY9
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Il22
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: IL-22
EC number: —
Processing: Precursor
Secondary accessions: Q14BB3

Protein keywords

Technical term

3D-structureReference proteome

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Cellular component

Secreted

Domain

Signal

Related Products

Catalog	Name
101-M407	FGF-22
101-M266	CCL-22 (MDC)
103-M328	CCL-22 (MDC)
100-161S	IL-37 (IL-1F7)
100-161-L250	IL-37 (IL-1F7)
101-M784	IL-18 (IL-1F4)
100-161	IL-37 (IL-1F7)
100-161-L1000	IL-37 (IL-1F7)
100-161-L100	IL-37 (IL-1F7)
100-161-L500	IL-37 (IL-1F7)

Alternative Products

Catalog	Name
MBS8532850-01	IL-22
I8443-18N	Interleukin 22 (IL-22)
377428	IL-22 (Interleukin-22)
MBS590062-01	Interleukin-22 (IL-22)
RC252-33	IL-22, Interleukin-22, rat
RC212-33	IL-22, Interleukin-22, human
BE53321	Interleukin-22 (IL-22) ELISA
CYT-328-01	IL 22 Human
347910-01	IL-22 discontinued
MBS201107-01	Recombinant IL-22