IL-22

CAT: 0209-100-413-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-100-413-L1000Size:1000 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.
Synonyms
Interleukin-22, IL-TIF, Cytokine ZCYTO18
NCBI Gene ID
50616
UniProt
Q9GZX6
Accession Number
NP_065386.1
Accession Number mRNA
NM_020525.4
Chromosomal Location
12q15
Reactivity
Human
Cross Reactivity
Monkey, Human
Sequence
MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: Determined by its ability to stimulate the proliferation of HEK-Blue™ IL-22 reporter cells. Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells) . The expected ED50 for this effect is 0.7- 1.0 ng/ml.
Length
147
Form
Lyophilized
Molecular Weight
33.6 kDa
Host or Source
E. coli

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