IL-16 (129 aa)

• Description:

  IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.3 kDa protein consisting of 129 amino acid residues.

• Synonyms:

  IL16; LCF; NIL16; PRIL16; prIL-16

• NCBI Gene ID:

  3603

• UniProt:

  Q14005

• Accession Number:

  NP_004504.3

• Accession Number mRNA:

  NM_004513

• Chromosomal Location:

  15q26.3

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse, Leech

• Sequence:

  PDLNSSTDSA ASASAASDVS VESTAEATVC TVTLEKMSAG LGFSLEGGKG SLHGDKPLTI NRIFKGAASE QSETVQPGDE ILQLGGTAMQ GLTRFEAWNI IKALPDGPVT IVIRRKSLQS KETTAAGDS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Not available.

• Length:

  129

• Form:

  Lyophilized

• Molecular Weight:

  13.3 kDa

• Host or Source:

  E. coli