IL-16 (121 aa)

• Description:

  IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues.

• Synonyms:

  IL16; LCF; NIL16; PRIL16; prIL-16

• NCBI Gene ID:

  3603

• UniProt:

  Q14005

• Accession Number:

  NP_004504.3

• Accession Number mRNA:

  NM_004513

• Chromosomal Location:

  15q26.3

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability ot chemoattract human CD4+ T-Lymphocytes using a concentration range of 50.0-100.0 ng/ml.

• Length:

  121

• Form:

  Lyophilized

• Molecular Weight:

  12.4 kDa

• Host or Source:

  E. coli