GRO-gamma (CXCL3)

• Description:

  All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant human GRO-γ is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

• Synonyms:

  CXCL3; GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b

• NCBI Gene ID:

  2921

• UniProt:

  P19876

• Accession Number:

  NP_002081.2

• Accession Number mRNA:

  NM_002090.2

• Chromosomal Location:

  4q21

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Human, Mouse

• Sequence:

  ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.

• Length:

  73

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli