GRO-beta (CXCL2)

• Description:

  Human GROß is a member of the C-X-C family of chemokines and promotes neutrophil and basophil chemotaxis and degranulation. GROß like GROa specifically inhibits growth factor-stimulated proliferation of capillary endothelial cells in a dose-dependent manner. Human GROß is a 7.9 kDa protein containing 73 amino acid residues.

• Synonyms:

  CXCL2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

• NCBI Gene ID:

  2920

• UniProt:

  P19875

• Accession Number:

  NP_002080.1

• Accession Number mRNA:

  NM_002089.3

• Chromosomal Location:

  4q21

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Human, Mouse

• Sequence:

  APLATELRCQ CLQTLQGIHL KNIQSVKVKS PGPHCAQTEV IATLKNGQKA CLNPASPMVK KIIEKMLKNG KSN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract CXCR2 transfected 293 cells using a concentration range of 10.0-100.0 ng/ml.

• Length:

  73

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli