GDF-7

• Description:

  GDF-7 belongs to the TGF-β superfamily of growth and differentiation factors. It is expressed selectively by roof plate cells that are located in the developing embryonic central nervous system, and has been shown to influence the neuronal identity of cells within the central nervous system. GDF-7 has also been implicated in the formation, maintenance, and repair of certain cartilage and ligament tissue. Recombinant human GDF-7 is a 28 kDa disulfide linked homodimer containing two 129 amino acid residues.

• Synonyms:

  GDF7; BMP12

• NCBI Gene ID:

  151449

• UniProt:

  Q7Z4P5

• Accession Number:

  NP_878248.2

• Accession Number mRNA:

  NM_182828.2

• Chromosomal Location:

  2p24.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells.

• Length:

  129

• Form:

  Lyophilized

• Molecular Weight:

  28 kDa

• Host or Source:

  E. coli