GDF-15 / GDF15 Protein (His Tag) (Mature Form)

• Description:

  Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF) -β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

• Synonyms:

  GDF-15 Protein; HG Protein; MIC-1 Protein; MIC1 Protein; NAG-1 Protein; PDF Protein; PLAB Protein; PTGFB Protein

• Accession Number:

  NP_004855.2

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Label:

  His-Tag

• Assay Protocol:

  See Datasheet send with the product

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 90 % as determined by SDS-PAGE.

• Bioactivity:

  Immobilized Recombinant Human GDF-15 / GDF15 Protein (His Tag) (Mature Form) at 2 μg/mL (100 μL/well) can bind Recombinant Human GFRAL Protein (Fc Tag), the EC50 is 7.0-21.0 ng/mL.

• Length:

  122

• Form:

  Lyophilized or frozen liquid

• Buffer:

  50mM HAc, pH 2.9.

• Reconstitution:

  See Datasheet

• Molecular Weight:

  18.2 kDa (glycosylated)

• Storage Conditions:

  Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• Host or Source:

  Yeast