Epigen

• Description:

  Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.

• Synonyms:

  EPGN; EPG; epigen; PRO9904; ALGV3072

• NCBI Gene ID:

  255324

• UniProt:

  Q6UW88

• Accession Number:

  NP_001257922.1

• Accession Number mRNA:

  NM_001270993.1

• Chromosomal Location:

  4q13.3

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml.

• Length:

  72

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli