Eotaxin-2

• Description:

  Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant murine Eotaxin-2 is an 10.3 kDa protein containing 93 amino acid residues.

• Synonyms:

  Ccl24; CKb-6; MPIF-2; Scya24

• NCBI Gene ID:

  56221

• UniProt:

  Q9JKC0

• Accession Number:

  NP_062523.1

• Accession Number mRNA:

  NM_019577

• Chromosomal Location:

  5; 5 G1

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse, Human

• Sequence:

  VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100 ng/ml

• Length:

  93

• Form:

  Lyophilized

• Molecular Weight:

  10.3 kDa

• Host or Source:

  E. coli