Products for Research Use Only
RegisterLogin

CXCL2 / MIP-2 Protein

CAT: 0209-600-090-L1000Size: 1000 µgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0209-600-090-L1000Size:1000 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.
Synonyms
CINC-2a Protein; GRO2 Protein; GROb Protein; MGSA-b Protein; MIP-2a Protein; MIP2 Protein; MIP2A Protein; SCYB2 Protein
Accession Number
NP_002080.1
Reactivity
Human
Cross Reactivity
Human
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE.
Bioactivity
Data not available
Length
73
Form
Lyophilized or frozen liquid
Buffer
20 mM Tris, 1 M NaCl, pH 8.0
Reconstitution
See Datasheet
Molecular Weight
7.9 kDa
Storage Conditions
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Host or Source
E.coli

Related Products

CatalogName
103-P31MIP-2 (CXCL2)
M10-037-L1000MIP-2 (CXCL2, Gro-beta)
M10-037-L500MIP-2 (CXCL2, Gro-beta)
M10-037-L50MIP-2 (CXCL2, Gro-beta)
M10-037MIP-2 (CXCL2, Gro-beta)
M10-037-L100MIP-2 (CXCL2, Gro-beta)
M10-037SMIP-2 (CXCL2, Gro-beta)
M10-037-L250MIP-2 (CXCL2, Gro-beta)
103-M360CXCL2
100-364Viral-MIP-2

Alternative Products

CatalogName
MBS9148961-01Recombinant Mouse CXCL2/MIP-2 Protein
RP01857-01Recombinant Human CXCL2/MIP-2 Protein
CD00295Recombinant Mouse MIP-2/CXCL2 protein
PROTP10889-1Recombinant Murine MIP-2 (CXCL2) Protein
P514614CXCL2/MIP-2 Protein (N-Sumo, Mouse)
P514615CXCL2; MIP-2 Protein (N-His, Mouse)
P514616CXCL2; MIP-2 Protein (N-His, Human)
M1202-52DMacrophage Inflammatory Protein 2 (MIP-2, CXCL2) (Biotin)
PROTP30348-1Recombinant Rat GRO-Beta /MIP-2 (CXCL2) Protein
MBS2580787-01Recombinant Mouse CXCL2/MIP-2 Protein (Sumo Tag)

Popular Products