CXCL16

• Description:

  CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal “mucin-like stalk” sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog) . Recombinant murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

• Synonyms:

  Cxcl16; SR-PSOX; Zmynd15; AV290116; BB024863; CXCL16v1; CXCL16v2; 0910001K24Rik

• NCBI Gene ID:

  66102

• UniProt:

  Q8BSU2

• Accession Number:

  NP_075647

• Accession Number mRNA:

  NM_023158

• Chromosomal Location:

  11; 11 B4

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract murine lymphocytes using a concentration of 20-1000 ng/ml.

• Length:

  88

• Form:

  Lyophilized

• Molecular Weight:

  9.9 kDa

• Host or Source:

  E. coli