CD40 Ligand/TRAP, soluble

CAT: 0209-100-115-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-115-L100Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
Synonyms
CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
NCBI Gene ID
959
UniProt
P29965
Accession Number
NP_000065.1
Accession Number mRNA
NM_000074.2
Chromosomal Location
Xq26
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human, Bacteria
Sequence
MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: Determined by the stimulation of IL-12 induction by human PBMCs. Assay #2: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The expected ED50 for this effect is 5-10 ng/ml. Note: Results may vary with PBMC donors.
Length
149
Form
Lyophilized
Molecular Weight
16.3 kDa
Host or Source
E. coli

Related Products

CatalogName
102-P108GCD40 Ligand
101-M682TNFSF5 (CD40 ligand)
101-M849TNFSF5 (CD40 Ligand)
S01-052-L100OX40 ligand, soluble
S01-041-L100CD27 ligand, soluble
S01-041-L500CD27 ligand, soluble
S01-041-L1000CD27 ligand, soluble
100-157-L100FAS Ligand, soluble
100-157-L500FAS Ligand, soluble
S01-041SCD27 ligand, soluble

Alternative Products

CatalogName
PR27033-01CD40 Ligand/TRAP (Soluble)
abx260744-01Soluble CD40 Ligand / TRAP Protein
MBS691869-01Mouse CD40 Ligand/TRAP, soluble
MBS692167-01Human CD40 Ligand/TRAP, soluble
MBS142122-01Recombinant Human soluble CD40 Ligand/TRAP
7-01476Recombinant Mouse soluble CD40 Ligand/TRAP
22060485-1Human soluble CD40 Ligand/TRAP (Recombinant)
MBS141159-01Recombinant Mouse soluble CD40 Ligand/TRAP sf9
7-01473Recombinant Human soluble CD40 Ligand/TRAP His Tag
MBS555521-01Recombinant Human soluble CD40 Ligand/TRAP (sCD40 Human)

Popular Products