BRAK (CXCL14)

• Description:

  Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

• Synonyms:

  CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

• NCBI Gene ID:

  9547

• UniProt:

  O95715

• Accession Number:

  NP_004878.2

• Accession Number mRNA:

  NM_004887.4

• Chromosomal Location:

  5q31

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human, Bacteria

• Sequence:

  SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  98% by SDS-PAGE & HPLC analysis

• Bioactivity:

  Determined by it's ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.

• Length:

  77

• Form:

  Lyophilized

• Molecular Weight:

  9.4 kDa

• Host or Source:

  E. coli