BD-1 (47aa)

CAT: 0209-100-133-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-133-L100Size:100 µg
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Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.
Synonyms
DEFB1; BD1; HBD1; DEFB-1; DEFB101
NCBI Gene ID
1672
UniProt
P60022
Accession Number
NP_5209.1
Accession Number mRNA
NM_005218
Chromosomal Location
8p23.1
Reactivity
Human
Cross Reactivity
Human
Sequence
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ng/ml.
Length
47
Form
Lyophilized
Molecular Weight
5.0 kDa
Host or Source
E. coli

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