Activin-A

• Description:

  Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

• Synonyms:

  Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone) -releasing protein

• NCBI Gene ID:

  3624

• UniProt:

  P08476

• Accession Number:

  NP_002183.1

• Accession Number mRNA:

  NM_002192.2

• Chromosomal Location:

  7p15-p13

• Reactivity:

  Human/Mouse/Rat

• Cross Reactivity:

  Human, Mouse, Rat

• Sequence:

  GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

• Length:

  116

• Form:

  Lyophilized

• Molecular Weight:

  26.0 kDa

• Host or Source:

  CHO cells