Recombinant Caspase-7 Monoclonal Antibody

• Background:

  Caspase-7, also named as CMH-1, Mch3 and ICE-LAP3, has been identified as a major contributor to the execution of apoptosis. Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as ADP-ribose polymerase and PARP. During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits. Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD.

• Abbreviation:

  Caspase-7

• UniProt:

  P97864

• Host:

  Rabbit

• Reactivity:

  Rat; Mouse

• Immunogen:

  Recombinant human Caspase-7 fragment

• Target:

  Mch; Lice; CASP; Lice2; Mch3; Casp7; CASP-7; Caspase 7; CMH-1; ICE-LAP3

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A586

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000; IHC 1:200-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  34 kDa

• Observed Molecular Weight:

  34 kDa

• Isotype:

  IgG, κ