Recombinant MTAP Monoclonal Antibody

• Background:

  MTAP is an enzyme essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine. MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma, thereby implicating its potential function as a tumor suppressor.

• Abbreviation:

  MTAP

• UniProt:

  Q13126

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Recombinant human MTAP fragment

• Target:

  HEL; MTAP; BDMF; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP; c86fus;5' methylthioadenosine phosphorylase;5''-methylthioadenosine phosphorylase; Epididymis luminal protein 249; HEL 249; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A519

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Signal Transduction; Metabolism

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-1:3000; IHC 1:50-1:100

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  31 kDa

• Observed Molecular Weight:

  31 kDa

• Isotype:

  IgG, κ