Recombinant Phospho-JNK1, 2, 3 (Thr183, Thr183, Thr221) Monoclonal Antibody

• Background:

  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

• Abbreviation:

  JNK1, 2, 3

• UniProt:

  P45983; P45984; P53779

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  A synthetic peptide corresponding to residues around (Thr183, Thr183, Thr221) of Human Phospho-JNK1, 2, 3

• Target:

  MAPK; PRKM; SAPK; JNK1A; JNK21B; MAPK8; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c; AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JNK 1; MAP kinase 8; MAPK 8; Mitogen activated protein kinase 8; mitogen-activated; Mitogen-activated protein kinase 8; MK08; p54 gamma; Protein kinase; Protein kinase JNK1; SAPK 1; SAPK gamma; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; JNK1/2/3

• Clonality:

  Monoclonal, Recombinant

• Clone:

  6H10

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Signal Transduction; Cancer; Immunology; Epigenetics and Nuclear Signaling

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  48 kDa

• Observed Molecular Weight:

  46,54 kDa

• Isotype:

  IgG, κ