NOTCH1 Polyclonal Antibody

CAT: 0763-E-AB-12815-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-12815-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Abbreviation
NOTCH1
UniProt
P46531
Host
Rabbit
Reactivity
Human; Rat
Immunogen
Synthetic peptide of human NOTCH1
Target
HN1; Neurogenic locus Notch homolog protein 1; NICD; NOTC1; Notch 1; Notch 1 intracellular domain; Notch homolog 1 translocation associated (Drosophila) ; notch1; TAN1; Translocation-associated notch protein TAN-1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Developmental Biology; Neuroscience; Stem Cells
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
273kDa
Citation 01
https://academic.oup.com/humrep/article-abstract/37/Supplement_1/deac104.075/6620257
Citation 02
https://www.mdpi.com/1948780
Citation 03
https://journals.sagepub.com/doi/abs/10.1177/1545968320925474
Citation 04
https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13413
Isotype
IgG

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