Recombinant CD45 Monoclonal Antibody

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

• Abbreviation:

  CD45

• UniProt:

  P08575

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant Human CD45 protein

• Target:

  B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; PTPRC; CD45 antigen; CD45R0; Ly-5; protein tyrosine phosphatase; receptor type; Receptor-type tyrosine-protein phosphatase C; CD45RO; Receptor-type tyrosine-protein phosphatase CLeukocyte common antigen (L-CA) ; T200; c polypeptide; CD 45; homolog of; Leukocyte common antigen; loc; Lyt-4; OTTHUMP00000033813; OTTHUMP00000033816; OTTHUMP00000033817; OTTHUMP00000038574; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase; receptor type; C; receptor type C; T200 glycoprotein; T200 leukocyte common antigen; B220; CD45; CD45 antigen; CD45R; GP180; L-CA; LCA; Ly-5; LY5; Protein tyrosine phosphatase; receptor type; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200

• Clonality:

  Monoclonal, Recombinant

• Clone:

  8C8

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Immunology; Signal Transduction; Neuroscience; Stem Cells; Cardiovascular

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  IHC 1:1000-1:10000; WB 1:1000-1:5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  147 kDa

• Observed Molecular Weight:

  240-200 kDa

• Isotype:

  IgG, κ