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Recombinant eIF2α Monoclonal Antibody

CAT: 0763-AN300883L-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0763-AN300883L-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161) . The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]) .
Abbreviation
EIF2α
UniProt
P05198
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human eIF2α protein
Target
EIF2S; EIF; EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A; EIF2S1; EIF 2; EIF 2 alpha; EIF 2A; EIF 2alpha; EIF2 alpha; eIF-2-alpha; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit 1 alpha; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa; Eukaryotic translation initiation factor 2 subunit alpha; IF2A
Clonality
Monoclonal, Recombinant
Clone
5C3
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
36 kDa
Observed Molecular Weight
36 kDa
Isotype
IgG, κ

UniProtKB · P05198

Eukaryotic translation initiation factor 2 subunit 1

IF2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05198
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF2S1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmMitochondrion

Molecular function

Initiation factorRNA-binding

Biological process

Protein biosynthesisTranslation regulation

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