Recombinant Dnmt1 Monoclonal Antibody

• Background:

  This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

• Abbreviation:

  DNMT1

• UniProt:

  P26358

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human Dnmt1 protein

• Target:

  MGC; CXXC; DNA methyltransferase; CXXC finger protein 9|DNA methyltransferase; ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1; CXXC finger protein 9|DNA methyltransferase 1; DNA methyltransferase 1; FLJ16293; MGC104992; ADCADN; AIM; CXXC9; DNA methyltransferase 1; DNMT; HSN1E; m.HsaI; MCMT; CXXC finger protein 9; CXXC-type zinc finger protein 9; DNA (cytosine 5) methyltransferase 1; DNA (cytosine-5) -methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase M.HsaI.; DNA MTase; DNA MTase HsaI; DNMT 1; Dnmt1o; Met1; mMmul; MommeD2

• Clonality:

  Monoclonal, Recombinant

• Clone:

  2D10

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Epigenetics and Nuclear Signaling

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  183 kDa

• Observed Molecular Weight:

  183 kDa

• Isotype:

  IgG, κ