Recombinant PUMA Monoclonal Antibody

• Background:

  This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

• Abbreviation:

  PUMA

• UniProt:

  Q9BXH1

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human PUMA protein

• Target:

  BBC; PUMA; BBC3; BBC 3; BBC3_HUMAN; BCL 2 binding component 3; BCL2 binding component 3; Bcl-2-binding component 3; JFY 1; JFY1; JFY-1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; p53 up-regulated modulator of apoptosis; PUMA alpha; PUMA/JFY1

• Clonality:

  Monoclonal, Recombinant

• Clone:

  4B14

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cell Biology; Signal Transduction; Cancer; Metabolism

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  21 kDa

• Observed Molecular Weight:

  21 kDa

• Isotype:

  IgG, κ