Recombinant Phospho-β Catenin (Thr41, Ser45) Monoclonal Antibody

• Background:

  The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

• Abbreviation:

  Β Catenin

• UniProt:

  P35222

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  A synthetic peptide corresponding to residues around (Thr41, Ser45) of Human Phospho-β Catenin

• Target:

  MRD; PRO; Catenin beta; SW-cl; OK/SW-cl; CTNNB; MRD19; armadillo; beta Catenin; CTNNB1; Beta-catenin; Catenin beta-1; OK; SW-cl.35; OK/SW-cl.35; PRO2286;88kDa; beta 1; Cadherin associated protein; Catenin (cadherin associated protein) ; Catenin beta 1; CATNB; CHBCAT; CTNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289; Catenin-β

• Clonality:

  Monoclonal, Recombinant

• Clone:

  6H9

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Signal Transduction; Neuroscience; Stem Cells; Cancer; Cardiovascular

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  WB 1:2000-1:10000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  86 kDa

• Observed Molecular Weight:

  92 kDa

• Isotype:

  IgG, κ