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Recombinant eIF4E Monoclonal Antibody

CAT: 0763-AN300668L-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0763-AN300668L-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
Abbreviation
EIF4E
UniProt
P06730
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human eIF4E protein
Target
AUTS; EIF4EL; AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F; eIF-4E; EIF4E; eIF-4F 25 kDa subunit; Eukaryotic translation initiation factor 4E; mRNA cap-binding protein
Clonality
Monoclonal, Recombinant
Clone
2C6
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
25 kDa
Isotype
IgG, κ

UniProtKB · P06730

Eukaryotic translation initiation factor 4E

IF4E_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06730
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF4E
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
eIF-4E, eIF4E
EC number
—
Processing
—
Secondary accessions
B7Z6V1, D6RCQ6, Q96E95
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Disease

AutismAutism spectrum disorder

Cellular component

CytoplasmNucleus

Biological process

Host-virus interactionmRNA transportProtein biosynthesisTranslation regulationTransport

Molecular function

Initiation factorRNA-binding

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