Recombinant CD16/FCGR3 Monoclonal Antibody

• Background:

  Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR) . FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16) . CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

• Abbreviation:

  FCGR3

• UniProt:

  P08508

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant Mouse CD16/FCGR3 protein

• Target:

  CD-antigen; Fcgr; CD16; CD16 Protein; CD-antigen 16; Fc gamma Receptor III; FcRIII; IgG Fc receptor III; Low affinity immunoglobulin gamma Fc region receptor III; Mouse; Fcgr3

• Clonality:

  Monoclonal

• Clone:

  9C1

• Conjugation:

  Unconjugated

• Applications:

  WB; IP

• Purification:

  Protein A

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000; IP 0.5-2 μL/mg of lysate

• Buffer:

  0.2 μm filtered solution in PBS

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  29 kDa

• Observed Molecular Weight:

  38 kDa

• Isotype:

  IgG