Recombinant CD27 Monoclonal Antibody

• Background:

  CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

• Abbreviation:

  CD27

• UniProt:

  P41272

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant Mouse CD27 protein

• Target:

  Tnfrsf; Tnfrsf7; Cd27; T14; S152; TNFRSF7; CD27 antigen; CD27L receptor; S152; T-cell activation antigen CD27; Tp55; Tumor necrosis factor receptor superfamily member 7

• Clonality:

  Monoclonal

• Clone:

  4D10

• Conjugation:

  Unconjugated

• Applications:

  FCM; ICC/IF

• Purification:

  Protein A

• Concentration:

  1 mg/mL

• Dilution:

  ICC/IF 1:20-1:100; FCM 1:25-1:100

• Buffer:

  0.2 μm filtered solution in PBS

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

• Isotype:

  IgG