IL-24 Recombinant Protein

• Background:

  IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.

• NCBI Gene ID:

  11009

• Swiss Prot:

  Q13007

• Accession Number:

  NP_001172085.1

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Cancer, Immunology

• Purity:

  Greater than 95% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized IL-24 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-24 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-24 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Interleukin 24

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  C49A, FISP, MDA7, MOB5, ST16, IL10B, Interleukin-24, Melanoma differentiation-associated gene 7 protein, IL-24

• Species:

  Human

• Protein ID:

  297632401

• Physical Properties:

  Lyophilized