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Adiponectin Recombinant Protein

CAT: 0223-40-328-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-328-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages) . Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 25.9 kDa by SDS PAGE analysis under reducing conditions.
NCBI Gene ID
9370
Swiss Prot
Q15848
Accession Number
NP_001171271.1
Type
Recombinant Proteins
Source
High-5 Insect cells
Field of Research
Neuroscience, Obesity, Signal Transduction, Stem Cell
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Adiponectin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Adiponectin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Adiponectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Adiponectin, C1Q and collagen domain containing
NCBI Organism
Homo sapiens
Other Product Names
ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, ACDC, Adiponectin, 30 kDa adipocyte complement-related protein
Species
Human
Protein ID
295317372
Physical Properties
Lyophilized

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