Relaxin-3 Recombinant Protein

• Background:

  Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as "somatostatin-like” or "angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an "orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.

• NCBI Gene ID:

  117579

• Swiss Prot:

  Q8WXF3

• Accession Number:

  NP_543140.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Neuroscience, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Relaxin-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Relaxin-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Relaxin-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Relaxin 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  H3, RXN3, ZINS4, insl7, INSL7, UNQ6188/PRO20213, Relaxin-3, Insulin-like peptide INSL7, Insulin-like peptide 7

• Species:

  Human

• Protein ID:

  18254464

• Physical Properties:

  Lyophilized