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NOV Recombinant Protein

CAT: 0223-40-222-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-222-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules) ; the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK) .
NCBI Gene ID
4856
Swiss Prot
P48745
Accession Number
NP_002505.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Homeostasis
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized NOV recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted NOV is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing NOV recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Nephroblastoma overexpressed
NCBI Organism
Homo sapiens
Other Product Names
CCN3, NOVh, IBP-9, IGFBP9, IGFBP-9, CCN3, NOVH, Protein NOV homolog, CCN family member 3, NovH
Species
Human
Protein ID
4505423
Physical Properties
Lyophilized

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