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BD-4 Recombinant Protein

CAT: 0223-40-135-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-135-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α -defensins are distinguished from the β -defensins by the pairing of their three disulfide bonds. To date, four human β -defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β -defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β -defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β -defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
NCBI Gene ID
140596
Swiss Prot
Q8WTQ1
Accession Number
NP_525128.2
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized BD-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted BD-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing BD-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Defensin, beta 104A
NCBI Organism
Homo sapiens
Other Product Names
BD-4, DEFB4, hBD-4, DEFB-4, DEFB104, DEFB104B, Beta-defensin 104, Beta-defensin 4, BD-4
Species
Human
Protein ID
103485139
Physical Properties
Lyophilized

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