PAI-1 Recombinant Protein

• Background:

  Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA) . PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFα , glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases. Accordingly, PAI-1 has been implicated as an important molecular link between obesity and coronary disease. PAI-1 can also specifically bind vitronectin (VTN) to form a stable active complex with an increased circulatory half life relative to free PAI-1. Recombinant human PAI-1 is a 42.7 kDa protein containing 379 amino acid residues.

• NCBI Gene ID:

  5054

• Swiss Prot:

  P05121

• Accession Number:

  NP_000593.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized PAI-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PAI-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PAI-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PAI, PAI1, PAI-1, PLANH1, Plasminogen activator inhibitor 1, Endothelial plasminogen activator inhibitor, PAI

• Species:

  Human

• Protein ID:

  10835159

• Physical Properties:

  Lyophilized