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PAI-1 Recombinant Protein

CAT: 0223-40-126-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-126-01Size:0.002 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA) . PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFα , glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases. Accordingly, PAI-1 has been implicated as an important molecular link between obesity and coronary disease. PAI-1 can also specifically bind vitronectin (VTN) to form a stable active complex with an increased circulatory half life relative to free PAI-1. Recombinant human PAI-1 is a 42.7 kDa protein containing 379 amino acid residues.
NCBI Gene ID
5054
Swiss Prot
P05121
Accession Number
NP_000593.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized PAI-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PAI-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PAI-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
NCBI Organism
Homo sapiens
Other Product Names
PAI, PAI1, PAI-1, PLANH1, Plasminogen activator inhibitor 1, Endothelial plasminogen activator inhibitor, PAI
Species
Human
Protein ID
10835159
Physical Properties
Lyophilized

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