TGF beta 1 Recombinant Protein

• Background:

  The three mammalian isoforms of TGF-b, TGF-b1, b2, b3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-b isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-b1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-b1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

• NCBI Gene ID:

  8743

• Swiss Prot:

  P50591

• Accession Number:

  NP_001177871.1

• Type:

  Recombinant Proteins

• Field of Research:

  Apoptosis, Cancer, Growth Factors, Immunology

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TGF beta 1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TGF beta 1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TGF beta 1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TL2, APO2L, CD253, TRAIL, Apo-2L, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand

• Species:

  Human

• Protein ID:

  300193032

• Physical Properties:

  Lyophilized