NGF-beta Recombinant Protein

NGF-beta Recombinant Protein

• Description: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
• Synonyms: NGF; NGFB; HSAN5; Beta-NGF
• CAS Number: 9000-83-3
• NCBI Gene ID: 4803
• UniProt: P01138
• Accession Number: NP_002497.2
• Accession Number mRNA: NM_002506
• Gene Location: 1p13.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Chicken, Hamster, Mouse, Rat, Human, Leech
• Sequence: SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
• Detection Range: Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analysis
• Length: 240
• Form: Lyophilized
• Molecular Weight: 13.5 kDa
• Shipping Conditions: Room Temperature