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NGF-beta Recombinant Protein

CAT: 0209-100-084SSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0209-100-084SSize:5 µg
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Description
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
CAS Number
9000-83-3
Synonyms
NGF; NGFB; HSAN5; Beta-NGF
NCBI Gene ID
4803
UniProt
P01138
Accession Number
NP_002497.2
Accession Number mRNA
NM_002506
Gene Location
1p13.1
Host
E. coli
Origin Species
Human
Species Reactivity
Chicken, Hamster, Mouse, Rat, Human, Leech
Sequence
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
Detection Range
Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Endotoxin
< 0.1 ng/µg of protein (<1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Length
240
Form
Lyophilized
Molecular Weight
13.5 kDa
Shipping Conditions
Room Temperature

UniProtKB · P01138

Beta-nerve growth factor

NGF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01138
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NGF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Beta-NGF
EC number
—
Processing
Precursor
Secondary accessions
A1A4E5, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variantNeurodegenerationNeuropathy

Cellular component

EndosomeSecreted

Molecular function

Growth factorMetalloenzyme inhibitorMetalloprotease inhibitorProtease inhibitor

Ligand

Lipid-binding

Domain

Signal

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