TIM-1 Antibody

• Background:

  TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

• NCBI Gene ID:

  171283

• Swiss Prot:

  Q5QNS5

• Accession Number:

  Q5QNS5.2

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  9927

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Relative Expression Validation (Figure 1) : Anti-TIM-1 antibodies (9927) specificity was further verified by TIM-1 relative expression. TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue) . Relative Expression Validation9927) TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue

• Field of Research:

  Immunology, Neuroscience, Signal Transduction, Growth Factors

• Purification:

  TIM-1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1405 – Mouse Kidney lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Human: (63%) .

• Buffer:

  TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TIM-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .

• Symbol:

  HAVCR1

• Positive Control 2:

  Cat. No. 1416 – Mouse Testis lysate

• Positive Control 3:

  Cat. No. 1464 – Rat Liver lysate

• NCBI Official Name:

  Hepatitis A virus cellular receptor 1

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Feigelstock et al. J. Virol. 1998; 72:6621-8

• Background Reference 02:

  Ichimura et al. J. Biol. Chem. 1998; 273:4135-42

• Background Reference 03:

  Meyers et al. Mol. Med. 2005; 11:362-9

• Background Reference 04:

  Mayers et al. Nat. Immunol. 2005;6:455-64.

• Other Product Names:

  TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1

• Tested Applications:

  ELISA, WB

• Protein ID:

  73919878

• Physical Properties:

  Liquid