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TIM-1 Antibody

CAT: 0223-9927-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-9927-01Size:0.02 mg
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Background
TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
NCBI Gene ID
171283
Swiss Prot
Q5QNS5
Accession Number
Q5QNS5.2
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
9927
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Relative Expression Validation (Figure 1) : Anti-TIM-1 antibodies (9927) specificity was further verified by TIM-1 relative expression. TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue) . Relative Expression Validation9927) TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue
Field of Research
Immunology, Neuroscience, Signal Transduction, Growth Factors
Purification
TIM-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 – Mouse Kidney lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Human: (63%) .
Buffer
TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TIM-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .
Symbol
HAVCR1
Positive Control 2
Cat. No. 1416 – Mouse Testis lysate
Positive Control 3
Cat. No. 1464 – Rat Liver lysate
NCBI Official Name
Hepatitis A virus cellular receptor 1
NCBI Organism
Mus musculus
Background Reference 01
Feigelstock et al. J. Virol. 1998; 72:6621-8
Background Reference 02
Ichimura et al. J. Biol. Chem. 1998; 273:4135-42
Background Reference 03
Meyers et al. Mol. Med. 2005; 11:362-9
Background Reference 04
Mayers et al. Nat. Immunol. 2005;6:455-64.
Other Product Names
TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1
Tested Applications
ELISA, WB
Protein ID
73919878
Physical Properties
Liquid

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