Adipolean Antibody (biotin)

• Background:

  Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.

• NCBI Gene ID:

  9370

• Swiss Prot:

  Q15848

• Accession Number:

  Q15848

• Host:

  Goat

• Reactivity:

  Human

• Immunogen:

  Produced from sera of goats pre-immunized with highly pure (>98%) recombinant (human Adipolean) .

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Primary Antibodies, Antibody Pairs

• Field of Research:

  Obesity

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Adipolean antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

• Symbol:

  ADIPOQ

• NCBI Official Name:

  Adiponectin, C1Q and collagen domain containing

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, ACDC, Adiponectin, 30 kDa adipocyte complement-related protein

• Tested Applications:

  WB

• Protein ID:

  2493789

• Physical Properties:

  Lyophilized