VISTA Antibody [6D2]

• Background:

  VISTA Antibody: VISTA/B7-H5/platelet receptor Gi24 is a single-pass type I membrane protein located at the cell surface. It is an immunoregulatory receptor which can inhibit T-cell response and may promote differentiation of embryonic stem cells, by inhibiting the BMP4 signaling pathway. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation.

• NCBI Gene ID:

  64115

• Swiss Prot:

  Q9H7M9

• Accession Number:

  NP_071436

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  VISTA antibody was raised against the extracellular domain of human VISTA.

• Clonality:

  Monoclonal

• Clone:

  6D2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  VISTA Antibody is supplied as protein A purified IgG1.

• Positive Control:

  Cat. No. 1331 - Human Lymphoma Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  VISTA Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  VISTA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  VSIR

• Positive Control 2:

  Cat. No. 1306 - Human Spleen Tissue

• NCBI Official Name:

  VISTA molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mayya V., et al . Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. 2009, Sci. Signal. 2:RA46-RA46.

• Background Reference 02:

  Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374.

• Other Product Names:

  VISTA Antibody: VISTA molecule, VSIR, B7-H5, B7H5, GI24, PP2135, SISP1, DD1alpha, VISTA, C10orf54, chromosome 10 open reading frame 54, PD-1H, V-set immunoregulatory receptor, V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation, Chromosome 10 Open Reading Frame 54

• Tested Applications:

  ELISA, IHC-P, ICC, IF, Flow

• Protein ID:

  64115

• Physical Properties:

  Liquid