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CTLA4 Antibody [8A1]

CAT: 0223-RF16013-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-RF16013-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells (1,2) . Both it and the homologous T-cell co-stimulatory protein CD28 bind to CD80 (B7-H1) and CD86 (B7-H2) on antigen-presenting cells (APCs) (3) . Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases (4) . CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer (5) .
NCBI Gene ID
1493
Swiss Prot
P16410
Accession Number
NP_005205
Host
Mouse
Reactivity
Human
Immunogen
CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.
Clonality
Monoclonal
Clone
8A1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
CTLA-4 Antibody is supplied as protein A purified IgG1.
Positive Control
Cat. No. 1210 - HEK293 Lysate Cell Lysate
Concentration
1 mg/mL
Buffer
CTLA-4 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CTLA-4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
CTLA4
NCBI Official Name
Cytotoxic T-lymphocyte associated protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Brunet JF, Denizot F, Luciani MF, et al. A new member of the immunoglobulin superfamily--CTLA-4 . Nature 1987; 328:267–70.
Background Reference 02
Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994; 1:405–13.
Background Reference 03
Harding FA, McArthur JG, Gross JA, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992; 356:607–9.
Background Reference 04
Romo-Tena J, Gomez-Martin D, and Alcocer-Verela J. CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance. Autoimmun. Rev. 2013; 12:117.
Other Product Names
CTLA-4 Antibody: CTL4, cytotoxic T-lymphocyte associated protein 4, CD, GSE, GRD4, ALPS5, CD152, IDDM12, CELIAC3
Tested Applications
ELISA, WB, IHC-P, ICC, IF
Physical Properties
Liquid

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