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PD1 Antibody [8A4]

CAT: 0223-RF16002-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-RF16002-01Size:0.02 mg
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Background
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.
NCBI Gene ID
5133
Swiss Prot
Q15116
Accession Number
NP_005009
Host
Mouse
Reactivity
Human
Immunogen
PD-1 antibody was raised against the extracellular domain of human PD-1.
Clonality
Monoclonal
Clone
8A4
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
PD-1 Antibody is supplied as protein A purified IgG1.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
PD-1 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PD-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
PDCD1
Positive Control 2
Cat. No. 1315 - Human Tonsil Tissue Lysate
Positive Control 3
Cat. No. 1369 - Human Lymph node Tissue Lysate
Positive Control 4
Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 5
Cat. No. 10-001 - Human Breast Tissue Slide
Positive Control 6
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Programmed cell death 1
NCBI Organism
Homo sapiens
Background Reference 01
Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
Background Reference 02
Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
Background Reference 03
Zhong X, Bai C, Gao W, et al. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int. Immunol. 2004; 16:1181-8.
Background Reference 04
Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by the disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999; 11:141-51.
Other Product Names
PD-1 Antibody: PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PD1, Programmed cell death protein 1, Protein PD-1, PDCD1, PDCD-1
Tested Applications
ELISA, WB, IHC-P, ICC, IF
Protein ID
145559515
Physical Properties
Liquid

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