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KLF4 Antibody [4E5C3]

CAT: 0223-PM-6142-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-6142-01Size:0.02 mg
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Background
KLF4 Monoclonal Antibody: KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.
NCBI Gene ID
9314
Swiss Prot
O43474
Accession Number
AAH30811
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
KLF4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human KLF4.
Clonality
Monoclonal
Clone
4E5C3
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
KLF4 Monoclonal Antibody is Protein A purified.
Positive Control
Cat. No. 1404 - Mouse Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
KLF4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLF4 monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Specificity
At least three isoforms of KLF4 are known to exist; this antibody will detect all three. KLF4 antibody will not cross-react with other Kruppel-like family members.
Symbol
KLF4
NCBI Official Name
Kruppel-like factor 4 (gut)
NCBI Organism
Homo sapiens
Background Reference 01
Evans PM, Zhang W, Chen X, et al. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J. Bio. Chem. 2007; 282:33994-4002.
Background Reference 02
Carpenter MK, Rosler E, and Rao MS. Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells 2003; 5:79-88.
Background Reference 03
Takahashi K and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 1263:663-76.
Background Reference 04
Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322:949-53.
Other Product Names
KLF4 Antibody [4E5C3] : EZF, GKLF
Tested Applications
ELISA, WB
Protein ID
21410813
Physical Properties
Liquid

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