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MD-2 Antibody [1A2E3]

CAT: 0223-PM-4847-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-4847-01Size:0.02 mg
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Background
MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
NCBI Gene ID
23643
Swiss Prot
Q9Y6Y9
Accession Number
NP_056179
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2.
Clonality
Monoclonal
Clone
1A2E3
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
MD-2 Monoclonal Antibody is Protein A purified.
Positive Control
Cat. No. 95-108 - MD-2 Recombinant Protein
Concentration
1 mg/mL
Buffer
MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MD-2 monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Symbol
LY96
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Lymphocyte antigen 96
NCBI Organism
Homo sapiens
Background Reference 01
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Background Reference 02
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Background Reference 03
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Background Reference 04
Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
Other Product Names
MD-2 Antibody [1A2E3] : MD2, MD-2, ly-96, ESOP-1
Tested Applications
ELISA, WB, IHC-P, IF, ICC
Protein ID
223555998
Physical Properties
Liquid

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