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MD-2 Antibody

CAT: 0223-3289-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3289-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MD-2 Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
NCBI Gene ID
23643
Swiss Prot
Q9Y6Y9
Accession Number
NP_056179
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3289
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 1) : Anti-MD-2 antibodies (3289) detected human MD-2 recombinant protein at different concentrations. Recombinant Protein Test3289
Field of Research
Innate Immunity
Purification
MD-2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
MD-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MD-2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human MD-2 has 2 isoforms, including isoform 1 (160aa, 18kD) and isoform 2 (130aa, 15kD) . Mouse MD-2 has one isoform (160aa, 18kD) and Rat MD-2 also has one isoform (160aa, 18kD) . 3289 can detect human, mouse and rat.
Symbol
LY96
Positive Control 2
Cat. No. 1466 - Rat Spleen Tissue Lysate
Positive Control 3
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Lymphocyte antigen 96
NCBI Organism
Homo sapiens
Background Reference 01
O'Neill et al. Trends in Imm. 2003; 24:286-9.
Background Reference 02
Vogel. Mol. Interv. 2003; 3:466-77.
Background Reference 03
Takeda et al. Annu. Rev. Immunol. 2003; 21:335-76.
Background Reference 04
Janeway et al. Annu. Rev. Immunol. 2002; 20:197-216.
Other Product Names
MD-2 Antibody: MD2, MD-2, ly-96, ESOP-1, ESOP1, MD2, Lymphocyte antigen 96, Ly-96
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
223555998
Physical Properties
Liquid

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