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DC-SIGN Antibody [5D7]

CAT: 0223-PM-2347-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-PM-2347-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
NCBI Gene ID
30835
Swiss Prot
Q9NNX6
Accession Number
Q9NNX6
Host
Mouse
Reactivity
Human
Immunogen
A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Clonality
Monoclonal
Clone
5D7
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
DC-SIGN Monoclonal Antibody is Protein A purified.
Positive Control
Cat. No. 1314 - Human Thymus Tissue Lysate
Concentration
1 mg/mL
Buffer
DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DC-SIGN monoclonal antibody can be stored at -20˚ C, stable for one year.
Fragment
IgG1
Symbol
CD209
Positive Control 2
Cat. No. 1369 - Human Lymph node Tissue Lysate
NCBI Official Name
CD209 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.
Background Reference 02
Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001; 75:4664-72.
Background Reference 03
Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.
Background Reference 04
Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.
Other Product Names
DC-SIGN Antibody [5D7] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Tested Applications
ELISA, WB, IHC-P
Protein ID
46396012
Physical Properties
Liquid

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