CD62E/CD62P Antibody [1.2B6]

• Background:

  CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1) . It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues. CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.

• NCBI Gene ID:

  6401

• Swiss Prot:

  P16581

• Accession Number:

  P16581

• Host:

  Mouse

• Reactivity:

  Human, Pig

• Immunogen:

  TNF stimulated human endothelial cells

• Clonality:

  Monoclonal

• Clone:

  [1.2B6]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Concentration:

  0.1 mg/mL

• Buffer:

  Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG1

• Specificity:

  CD62E/CD62P

• Applications Notes:

  CD62E/CD62P Antibody [1.2B6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, adhesion, and blocking assays.

• Symbol:

  SELE

• NCBI Official Name:

  E-selectin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  E-selectin, P-selectin, ELAM-1, LECAM-2, PADGEM, GMP-140, LECAM-3

• Tested Applications:

  Flow

• Physical Properties:

  Liquid